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desR [2017-8-11 16:0:3]
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desR [2017-8-11 16:0:3]

two-component response regulator, regulation of cold shock expression of des
locus
BSU19200
pI
4.89
mw
22.03 kDa
protein length
199 aa Sequence Blast
gene length
597 bp Sequence Blast
function
regulation of cold shock expression of des
product
two-component response regulator
essential
no
synonyms
yocG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.1|Two-component system response regulators]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.5|Cold stress proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.2|Phosphorylation on an Asp residue]

    • Gene

    Coordinates
    2,091,705 → 2,092,304

    The protein

    Catalyzed reaction/ biological activity

  • transcription activation of the ''[gene|644C0C354B72FC07222EE45F4D2E0E57434B5EB5|des]'' operon when phosphorylated by [protein|C5F9A1970393625B01C05C72C9A240C8EE8789D3|DesK]

    • Modification

  • phosphorylated by [protein|C5F9A1970393625B01C05C72C9A240C8EE8789D3|DesK] on an Asp residue

    • Structure

  • [PDB|5IUJ] ([protein|C5F9A1970393625B01C05C72C9A240C8EE8789D3|DesK]-[protein|F08BE4ACC0ECE1416B012CA72B027423D4D9B00A|DesR] complex in the phosphotransfer state with low Mg2+ [20 mM]) [Pubmed|27938660]
  • [PDB|5IUK] ([protein|C5F9A1970393625B01C05C72C9A240C8EE8789D3|DesK]-[protein|F08BE4ACC0ECE1416B012CA72B027423D4D9B00A|DesR] complex in the phosphotransfer state with high Mg2+ [150 mM] and BeF3) [Pubmed|27938660]
  • [PDB|5IUN] ([protein|C5F9A1970393625B01C05C72C9A240C8EE8789D3|DesK]-[protein|F08BE4ACC0ECE1416B012CA72B027423D4D9B00A|DesR] complex in the phosphatase state) [Pubmed|27938660]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    genes
    [gene|C5F9A1970393625B01C05C72C9A240C8EE8789D3|desK]-[gene|F08BE4ACC0ECE1416B012CA72B027423D4D9B00A|desR]
    description
    [Pubmed|11285232]

    regulation

  • induced by cold shock (12-fold) [Pubmed|12399512]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A320 (yocG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/320 NBRP B. subtilis, Japan]

    • Labs working on this gene/protein

  • [SW|Diego de Mendoza], Universidad Nacional de Rosario, Argentine [http://www.ibr.gov.ar/eng/investigacion/demendoza.htm homepage]

    • References

  • 10094672,12399512,19595746,11285232,17087771,12207704,25406381,27938660